Designing a preliminary adaptive study to inform a biomarker trial in Psoriasis
نویسندگان
چکیده
Background Biomarkers play different roles in trials, being accordingly classified into ‘prognostic’, ‘predictive’, ‘surrogate’, or combinations thereof. Knowledge of a biomarker’s role enables focused testing in late Phase trials through a better choice from available designs (e.g. ‘stratified’, ‘strategy’, and ‘enrichment’). Preliminary studies can inform a biomarker’s role and the relative value of multiple biomarkers.
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2011